The EASL clinical practice guidelines for extrahepatic cholangiocarcinoma (eCCA) offer an updated, clinically oriented resource to support clinicians in the accurate diagnosis and management of this malignancy. Developed using the PICO framework (Patient/Problem/Population, Intervention, Comparison, Outcome), the guidelines address six core topics: Classification, Epidemiology, Surveillance/Early Diagnosis, Diagnosis/Staging, Therapy, and Follow-up. Each section focuses on the most relevant and challenging aspects, emphasizing the need for precise classification, integration of emerging molecular insights, and practical diagnostic and therapeutic strategies tailored to real-world clinical practice.